A Disintegrin And Metalloprotease 10 (ADAM10) and ADAM17 are the major shedding and reveals a novel cleavage site of ADAM Using mass spectrometry we determined the proteolytic cleavage sites in the APLP2 sequence. ADAM10 was found to cleave APLP2 after. Notch receptors are type I transmembrane glycoproteins that undergo furin cleavage at site 1 (S1) during transit to the cell surface. S1-cleaved. J Proteome Res. Apr 4;13(4) doi: /pru. Epub Mar LC-MS based cleavage site profiling of the proteases ADAM10 and.
ADAM10 - Wikipedia
Changes in the expression levels or dysregulated proteolytic activity of ADAM10 and ADAM17 have been shown to play important roles in multiple diseases such as inflammation, cancer, and neurodegenerative disorders.
Overall, the precise identification of ADAM10 and ADAM17 cleavage site specificity provides the basis for better substrate identification in vivo and the generation of specific inhibitors or activity based probes. This material is available free of charge via the Internet at http: Type part of your institution name for a list of matches.
If your institution is not listed, please contact your librarian. Unable to find the university or organization name. ACS members enjoy benefits including 50 free articles a year and reduced priced individual subscription. Learn More. Technical Note. Previous Article. Next Article. Table of Contents. Proteome Res. Cite this: Your current credentials do not allow retrieval of the full adam10 cleavage site. Previously logged in from: Log In Again Forget this institution. No institution has been found.
Skip to search form Skip to main content. Changes in the expression levels or dysregulated proteolytic activity of ADAM10 and ADAM17 have been shown to play important roles in multiple diseases such as inflammation, cancer, and neurodegenerative disorders. Save to Library. Create Alert. View on PubMed. This paper has 52 citations. This paper has been referenced on Twitter 1 time. From This Paper Figures, tables, and topics from this paper.
Explore Further: Citations Publications citing this adam10 cleavage site. Showing of 29 extracted citations. Sort by: Influence Recency. Proteolytic Cleavage Governs Interleukin Trans-signaling. View 5 Excerpts. Highly Influenced. View 4 Excerpts. View 6 Excerpts. SeegarLauren B. Irreversible modifications of receptor tyrosine kinases. View 1 Excerpt. Mechanisms of receptor shedding in platelets. Prion Proteins Without the Glycophosphatidylinositol Anchor: View 3 Excerpts.
Citation Statistics 52 Citations 0 10 20 '14 '15 '16 '17 '18 ' Semantic Scholar estimates that this publication has 52 citations based on the available data.
See our FAQ for additional information. References Publications adam10 cleavage site by this paper. Showing of 36 references. Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their adam10 cleavage site proteolytic activity and cleavage site specificity.
Giada MarinoPitter F. Martin Blue dragon plus nds eu. BiniossekOliver Schilling. RawlingsMatthew WallerAlan J. BarrettAlex Bateman.